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NPR-C activator 1

CAS No. 2768328-61-4

NPR-C activator 1( —— )

Catalog No. M35566 CAS No. 2768328-61-4

NPR-C activator 1 (Compound 1) is a potent agonist (EC50 ~ 1 μM) of natriuretic peptide receptor C (NPR-C), which plays a crucial role in regulating vascular homeostasis, and demonstrates promising in vivo pharmacokinetic properties .

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    NPR-C activator 1
  • Note
    Research use only, not for human use.
  • Brief Description
    NPR-C activator 1 (Compound 1) is a potent agonist (EC50 ~ 1 μM) of natriuretic peptide receptor C (NPR-C), which plays a crucial role in regulating vascular homeostasis, and demonstrates promising in vivo pharmacokinetic properties .
  • Description
    NPR-C activator 1 (Compound 1) is a potent activator of natriuretic peptide receptor C (NPR-C). C-type natriuretic peptide (CNP) is involved in the regulation of vascular homeostasis. NPR-C activator 1 is identified as a potent agonist (EC50 ～ 1 μM) with promising in vivo pharmacokinetic properties.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Others
  • Target
    Other Targets
  • Recptor
    Others
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2768328-61-4
  • Formula Weight
    372.42
  • Molecular Formula
    C18H24N6O3
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(OC(C)(C)C)CCNC=1N=CN=C(N1)NC2=CC=C(C=C2)NC(=O)C
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Smith RJ, et al. A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. J Med Chem. 2022 Apr 14;65(7):5495-5513.?
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